We are entering a period of technological change that will redefine how work is done across every industry. In this keynote, Michael Domanic makes the case that AI transformation cannot be left to chance or even small innovation teams. It demands a formal, enterprise-wide program led from the center of the organization. This talk examines both the opportunity and the responsibility leaders face. On one hand, AI offers unprecedented potential to improve how work is performed. On the other, organizations have a duty to give their employees the tools, training, and guidance needed to engage with AI responsibly and remain relevant in a rapidly changing world. This session challenges leaders to rethink AI not as an experiment, but as a foundational transformation.